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History of Glutathione
Glutathione was discovered in the year 1888. Glutathione is such a ubiquitous and versatile functioning molecule that shortly after its discovery in 1888 by J. de Rey-Pailhade, this7, 8, 9 small tripeptide molecule was deemed so important with so many vital functions that it was considered coincident with the "origin of life."
Sir Frederick Gowland Hopkins (1861-1947) of Cambridge University is also credited with a role in Glutathione's discovery and characterization and its name. He received the Nobel Prize in 1929.
In many ways, glutathione is like a vitamin; glutathione has at least 15 functions, and there is a high turnover of glutathione in the body.
There is a constant turnover of GSH in the body, with the liver occupying a central position in this dynamic flux; turnover of GSH in normal liver, estimated in rodents and humans, approximates 20% per hour.10
Restoring the bodily levels of glutathione involved certain scientific challenges because of the chemical subtleties and technicalities presented by the amino acids involved in its synthesis, which synthesis process can only take place intracellularly. Glutathione is synthesized within every cell of the body.
Dr. Albert Crum, the founder of ProImmune Plus®, understood that L-Cysteine is the most important part of that synthesis process. He also understood that owing to its unstable nature and oxidizability, L-Cysteine needs to be guided safely into bodily cells to participate in Glutathione synthesis. He proclaimed via his Patent that L-Cystine, which is made of two L-Cysteines bound together, is the optimal natural physiologic carrier of L-Cysteine until it passes the cell wall, whereupon the two L-Cysteines can immediately participate in the synthesis of Glutathione. Dr. Dean P. Jones, Director of the Emory University School of Medicine Biomarkers Laboratory, has discussed a cysteine/cystine shuttle in which cystine is transported into cells reduced and released as cysteine. Alternatively, plasma membrane oxydoreductases could use cellular reductives to reduce cystine to cysteine without transport.11
How Your Body Processes Glutathione
Glutathione fights aging through at least two major pathways—your gut and your bloodstream.
One: When you eat glutathione, as in food or supplements, it gets into cells of your gastrointestinal tract and sets up a fat-detoxification system on the site, blocking an exportation of … oxidized fat throughout your body. However, how much glutathione gets to other parts of the body intact is uncertain, because digestive juices break down glutathione into other substances. Thus, glutathione from foods and supplements may not reach he bloodstream and other tissues and organs in sufficient amounts to make a major difference.13
Two: You can boost glutathione in your blood and consequently in all other tissues (indirectly) by consuming the chemical building blocks that form glutathione in the body.”13. 14
The medical community has observed, dissected and explored these parameters since the discovery of glutathione in 1888. No one has been able to access the indirect avenue that Introduces the components and chemistry necessary to Naturally and physiologically restore glutathione in the body…
Methylation- Glutathione and methylation are dependent on one another. Low methylation equals low glutathione and low glutathione slows methylation. This also means that improved glutathione levels equal improved methylation!
Immune Support- Intracellular Glutathione enhanced cells are able to produce more infection-fighting substances, controlling both bacterial and viral infections. Many chronic infections such as EBV, hepatitis, herpes virus and Lyme suppress the immune system; Glutathione can modulate and reverse this suppression.
Anti-Aging- Intracellular Glutathione is the body's main powerhouse for defusing and disposing of free radicals that bring on the woes of aging. It protects every cell, tissue and organ in the body. Further, it may determine the rate at which you age.
Athletic Recover- As the body recovers from athletic training, it needs to flush toxins from the body. Intracellular Glutathione comes in to clear out metabolic waste.
Brain Health- Intracellular Glutathione plays an important role in decreasing oxidative stress to the brain. This improves cognitive function, mood, and memory
Inflammation- Intracellular Glutathione controls inflammatory responses by instructing the immune cells. By rebalancing glutathione levels, chronic inflammation can be reduced.
Detoxification- Intracellular Glutathione allows for the body to neutralize and eliminate toxins effectively.